So, what Wikipedia explains on the example of steroid nuclear receptors, is that nuclear localization signal helps ligand bind to a receptor and on the receptor itself conformation change led by heat shock proteins enables passage via a membrane.ĭefinitely ligand itself wouldn't be able to pass phospholipid heads if it is not for receptor and Heat Shock Proteins. Upon binding by the hormone the receptor undergoes a conformational change releasing the HSP, and the receptor together with the bound hormone enters the nucleus to act upon transcription." This region of the receptor is covered up by heat shock proteins (HSPs) which bind the receptor until the hormone is present. Thank you Didn't find what you were looking for New post Post is closed for comments. This uptake into the nucleus is facilitated by a nuclear localization signal (NLS) found in the hinge region of the receptor. 2 years ago 1 Hi, I was wondering how helpful the AP Chemistry content is in studying for IB Chemistry HL. ![]() Depending upon the type of receptor, they are either located in the cytosol and move to the cell nucleus upon activation, or remain in the nucleus waiting for the steroid hormone to enter and activate them. ![]() "Steroid receptors of the nuclear receptor family are all transcription factors.
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